Everything about PACE is untenable … Thank you peter
Analysis and opinion by Peter Kemp MA
September 2016
[Emphases throughout are added]
This article follows-on from my Blog:
The PACE Trial ‘Normal Range’ – an Untenable Construct
https://wordpress.com/post/peterkempblog.wordpress.com/10
which analysed the PACE Trial authors’ justifications for discarding the Protocol Primary Outcome Measures and use of ‘Normal Range’ as a measure of efficacy for treatments.
As a reminder, here is how ‘Normal Range’ compares with the Primary Outcome Measures which the PACE Trial authors’ discarded. The chart is adapted directly from one published in The Lancet, with the addition of orange lines showing outcome thresholds.
And below is a table illustrating various interpretations of the ‘Normal Range’ SF36PF (Short Form 36 Physical Function subscale) threshold, showing that it is clinically meaningless, even to those that designed and employed it.
(White was the PACE Trial chief investigator, Bleijenberg and Knoop published a comment on the PACE Trial accompanying the PACE report…
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